Feigelson HS, Bodelon C, Powers JD, Curtis RE, Buist DSM, Veiga LHS, Aiello Bowles EJ, Berrington de González A, Gierach GL. Body Mass Index and Risk of Second Cancer among Women with Breast Cancer. J Natl Cancer Inst. 2021 Apr 5:djab053. doi: 10.1093/jnci/djab053. Epub ahead of print. PMID: 33823007.
We found a small but statistically significant increased risk for second cancers associated with increasing BMI (7% per 5 kg/m2). The association was more pronounced when the analysis was limited to cancers defined as “obesity-related”, or for second breast cancers. Obesity is associated with poor prognosis, inadequate response to cancer treatment and poor quality of life in patients with cancer. Moreover, weight loss has many proven benefits, not only for cancer but also for other diseases such as heart disease for which breast cancer survivors are at increased risk. BMI is a modifiable risk factor, and weight loss to reach a healthy body weight among breast cancer survivors may result in significant health and quality of life benefits.